2024

The importance of surface composition and wettability on the dissolution performance of high drug loading amorphous dispersion formulations
Hiew, T. N., Solomos, M. A., Kafle, P., Polyzois, H., Smith, D., Schenck, L., Taylor, L. S.
Journal of Pharmaceutical Sciences. Article in press

Mannitol-coated hydroxypropyl methylcellulose as a directly compressible controlled release excipient for moisture-sensitive drugs: A stability perspective
Kang, C. Y. X., Chow, K. T., Lui, Y. S., Salome, A., Boit, B., Lefevre, P., Hiew, T. N., Gokhale, R., Heng, P. W. S.
Pharmaceuticals. 17(9): 1167

Mannitol-coated hydroxypropyl methylcellulose as an alternative directly compressible controlled release excipient
Kang, C. Y. X., Foo, W. C., Lam, K. H., Chow, K. T., Lui, Y. S., Goh, H. P., Salome, A., Boit, B., Lefevre, P., Hiew, T. N., Gokhale, R., Heng, P. W. S.
International Journal of Pharmaceutics. 660: 124298

2023

Improving dissolution performance and drug loading of amorphous dispersions through a hierarchical particle approach
Hiew, T. N., Saboo, S., Zemlyanov, D. Y., Punia, A., Wang, M., Smith, D., Lowinger, M., Solomos, M. A., Schenck, L., Taylor, L. S.
Journal of Pharmaceutical Sciences. 112(8): 2057-2068

Influence of talc and hydrogenated castor oil on the dissolution behavior of metformin-loaded pellets with acrylic-based sustained release coating
Hiew, T. N., Siew, L. W., Wannaphatchaiyong, S., Elsergany, R. N., Pichayakorn, W., Boonme, P., Heng, P. W. S., Liew, C. V.
International Journal of Pharmaceutics. 640: 122984

Formulation and processing strategies which underpin susceptibility to matrix crystallization in amorphous solid dispersions
Moseson, D. E., Hiew, T. N., Su, Y., Taylor, L. S.
Journal of Pharmaceutical Sciences. 112(1): 108-122
Article included in the Journal of Pharmaceutical Sciences virtual issue for "Most Original and Most Significant Scientific Findings".

2022

Effect of drug load and lipid-wax blends on drug release and stability from spray-congealed microparticles
Ouyang, H., Ang, S. J., Lee, Z. Y., Hiew, T. N., Heng, P. W. S., Chan, L. W.
Pharmaceutical Development and Technology. 27(10): 1069-1082

Combining drug salt formation with amorphous solid dispersions – a double edged sword
Hiew, T. N., Taylor, L. S.
Journal of Controlled Release. 352: 47-60

Balancing solid-state stability and dissolution performance of lumefantrine amorphous solid dispersions: The role of polymer choice and drug–polymer interactions
Hiew, T. N., Zemlyanov, D. Y., Taylor, L. S.
Molecular Pharmaceutics. 19(2): 392-413
Article highlighted by the Editor-in-Chief as one of the top cited Molecular Pharmaceutics articles in 2023.

2021

Amorphous solid dispersions containing residual crystallinity: Competition between dissolution and matrix crystallization
Moseson, D. E., Corum, I. D., Lust, A., Altman K. J., Hiew, T. N., Eren, A., Nagy, Z. K., Taylor, L. S.
The AAPS Journal. 23, 69

2020

Insights into the moisture scavenging properties of different types of starch in tablets containing a moisture-sensitive drug
Veronica N., Hiew, T. N., Liew, C. V., Heng, P. W. S.
Molecular Pharmaceutics. 17(12): 4616-4628

A mechanistic understanding of compression damage to the dissolubility of coated pellets in tablets
Hiew T. N., Tian, Y. H., Tan, H. M., Heng, P. W. S.
European Journal of Pharmaceutics and Biopharmaceutics. 146: 93-100

2019

Understanding the release performance of pellets with hydrophobic inclusions in sustained-release coating
Hiew, T. N. Tan, D. L. H., Tiang, Y. L., Heng, P. W. S.
International Journal of Pharmaceutics. 557: 229-237

2018

A study of the impact of excipient shielding on initial drug release using UV imaging
Hiew, T. N., Alaudin, M. I. B., Chua, S. M., Heng, P. W. S.
International Journal of Pharmaceutics. 553(1-2): 229-237

2017

A study of moisture sorption and dielectric processes of starch and sodium starch glycolate
Hiew, T. N., Huang, R., Popov, I., Feldman, Y., Heng, P. W. S.
Pharmaceutical Research. 34(12):2675-2688

2016

Effect of moisture sorption on the performance of crospovidone
Hiew, T. N., Johan, N. A. B., Desai, P. M., Chua, S. M., Loh, Z. H., Heng, P. W. S.
International Journal of Pharmaceutics. 514(1): 322-331

In vitro dissolution of pharmaceutical solids
Hiew, T. N. and Heng, P. W. S.
In Oral Bioavailability and Drug Delivery: From Basics to Advanced Concepts and Applications (eds M. Hu and X. Li)